IGGCAS OpenIR  > 地球与行星物理院重点实验室
Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature
Yu, Jiacheng1,2; Cao, Changqian1,2; Fang, Fengjiao1,2,3; Pan, Yongxin1,2,3
2022-04-01
Source PublicationINTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume23Issue:7Pages:15
AbstractIron oxide nanoparticles have attracted a great deal of research interest in recent years for magnetic hyperthermia therapy owing to their biocompatibility and superior thermal conversion efficiency. Magnetoferritin is a type of biomimetic superparamagnetic iron oxide nanoparticle in a ferritin cage with good monodispersity, biocompatibility, and natural hydrophilicity. However, the magnetic hyperthermic efficiency of this kind of nanoparticle is limited by the small size of the mineral core as well as its low synthesis temperature. Here, we synthesized a novel magnetoferritin particle by using a recombinant ferritin from the hyperthermophilic archaeon Pyrococcus furiosus as a template with high iron atom loading of 9517 under a designated temperature of 90 degrees C. Compared with the magnetoferritins synthesized at 45 and 65 degrees C, the one synthesized at 90 degrees C displays a larger average magnetite and/or maghemite core size of 10.3 nm. This yields an increased saturation magnetization of up to 49.6 emu g(-1) and an enhanced specific absorption rate (SAR) of 805.3 W g(-1) in an alternating magnetic field of 485.7 kHz and 49 kA m(-1). The maximum intrinsic loss power (ILP) value is 1.36 nHm(2) kg(-1). These results provide new insights into the biomimetic synthesis of magnetoferritins with enhanced hyperthermic efficiency and demonstrate the potential application of magnetoferritin in the magnetic hyperthermia of tumors.
Keywordhyperthermophilic archaeon iron oxide nanoparticle magnetic hyperthermia magnetoferritin biomineralization
DOI10.3390/ijms23074012
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation
WOS KeywordOXIDE-BASED NANOPARTICLES ; FE3O4 NANOPARTICLES ; CANCER-CELLS ; FERRITIN ; ABSORPTION ; REDUCTION ; NANOCUBES ; PROTEIN ; FLUID
Language英语
Funding ProjectNational Natural Science Foundation of China[41774076] ; National Natural Science Foundation of China[41621004] ; Key Research Program of the Institute of Geology and Geophysics, CAS[IGGCAS-201903] ; PetroChina Innovation Foundation[2020D-5007-0105]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; Key Research Program of the Institute of Geology and Geophysics, CAS ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation ; PetroChina Innovation Foundation
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
WOS IDWOS:000781323300001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iggcas.ac.cn/handle/132A11/105094
Collection地球与行星物理院重点实验室
Corresponding AuthorCao, Changqian
Affiliation1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Innovat Acad Earth Sci, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Yu, Jiacheng,Cao, Changqian,Fang, Fengjiao,et al. Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature[J]. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,2022,23(7):15.
APA Yu, Jiacheng,Cao, Changqian,Fang, Fengjiao,&Pan, Yongxin.(2022).Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature.INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES,23(7),15.
MLA Yu, Jiacheng,et al."Enhanced Magnetic Hyperthermia of Magnetoferritin through Synthesis at Elevated Temperature".INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 23.7(2022):15.
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