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Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles
Cai, Yao1,2,3; Wang, Yuqing4; Xu, Huangtao1,2,3,5; Cao, Changqian1,2,3; Zhu, Rixiang3; Tang, Xu6; Zhang, Tongwei1,2; Pan, Yongxin1,2,3,5
2019-02-14
Source PublicationNANOSCALE
ISSN2040-3364
Volume11Issue:6Pages:2644-2654
AbstractIron oxide nanoparticles with good biocompatibility can serve as safe magnetic resonance imaging contrast agents. Herein, we report that ultrafine ferritin-based iron oxide (hematite/maghemite) nanoparticles synthesized by controlled biomimetic mineralization using genetically recombinant human H chain ferritin can be used as a positive contrast agent in magnetic resonance angiography. The synthesized magnetoferritin with an averaged core size of 2.2 +/- 0.7 nm (hereafter named M-HFn-2.2) shows a r1 value of 0.86 mM(-1) s(-1) and a r2/r1 ratio of 25.1 at a 7 T magnetic field. Blood pool imaging on mice using the M-HFn-2.2 nanoparticles that were injected through a tail vein by single injection at a dose of 0.54 mM Fe per kg mouse body weight enabled detecting detailed vascular nets at 3 minutes post-injection; the MR signal intensity continuously enhanced up to 2 hours post-injection, which is much longer than that of the commercial magnevist (Gd-DTPA) contrast. Moreover, biodistribution examination indicates that organs such as liver, spleen and kidney safely cleared the injected nanoparticles within one day after the injection, demonstrating no risk of iron overload in test mice. Therefore, this study sheds light on developing high-performance gadolinium free positive magnetic resonance contrast agents for biomedical applications.
DOI10.1039/c8nr06812g
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
WOS KeywordT-1 CONTRAST AGENTS ; H-FERRITIN ; GADOLINIUM DEPOSITION ; PROTEIN ; FERUMOXYTOL ; PHARMACOKINETICS ; DIAGNOSIS ; NANOCAGES ; PLATFORM ; TUMORS
Language英语
Funding ProjectNational Natural Science Foundation of China[41621004] ; National Natural Science Foundation of China[41704072] ; National Natural Science Foundation of China[41330104] ; National Natural Science Foundation of China[41574062] ; Key Program of Chinese Academy of Sciences[QYZDJ-SSW-DQC024] ; China Postdoctoral Science Foundation[2017M610979]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
WOS IDWOS:000459579400048
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iggcas.ac.cn/handle/132A11/90673
Collection地球与行星物理院重点实验室
Corresponding AuthorCai, Yao; Pan, Yongxin
Affiliation1.Chinese Acad Sci, Inst Geol & Geophys, Biogeomagnetism Grp, Key Lab Earth & Planetary Phys, Beijing 100029, Peoples R China
2.Chinese Acad Sci, France China Int Lab Evolut & Dev Magnetotact Mul, Beijing 100029, Peoples R China
3.Chinese Acad Sci, Inst Geol & Geophys, PGL, Beijing 100029, Peoples R China
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
6.Chinese Acad Sci, Inst Earth Sci, Transmiss Electron Microscope Lab, Beijing 100029, Peoples R China
Recommended Citation
GB/T 7714
Cai, Yao,Wang, Yuqing,Xu, Huangtao,et al. Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles[J]. NANOSCALE,2019,11(6):2644-2654.
APA Cai, Yao.,Wang, Yuqing.,Xu, Huangtao.,Cao, Changqian.,Zhu, Rixiang.,...&Pan, Yongxin.(2019).Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles.NANOSCALE,11(6),2644-2654.
MLA Cai, Yao,et al."Positive magnetic resonance angiography using ultrafine ferritin-based iron oxide nanoparticles".NANOSCALE 11.6(2019):2644-2654.
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