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Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field
Xu, Huangtao1,2,3; Pan, Yongxin1,2,3
2019-10-01
Source PublicationNANOMATERIALS
Volume9Issue:10Pages:14
AbstractThe superparamagnetic substance magnetoferritin is a potential bio-nanomaterial for tumor magnetic hyperthermia because of its active tumor-targeting outer protein shell, uniform and tunable nanosized inner mineral core, monodispersity and good biocompatibility. Here, we evaluated the heating efficiency of magnetoferritin nanoparticles in an alternating magnetic field (AMF). The effects of core-size, Fe concentration, viscosity, and field frequency and amplitude were investigated. Under 805.5 kHz and 19.5 kA/m, temperature rise (Delta T) and specific loss power (SLP) measured on magnetoferritin nanoparticles with core size of 4.8 nm at 5 mg/mL were 14.2 degrees C (at 6 min) and 68.6 W/g, respectively. The SLP increased with core-size, Fe concentration, AMF frequency, and amplitude. Given that: (1) the SLP was insensitive to viscosity of glycerol-water solutions and (2) both the calculated effective relaxation time and the fitted relaxation time were closer to Neel relaxation time, we propose that the heating generation mechanism of magnetoferritin nanoparticles is dominated by the Neel relaxation. This work provides new insights into the heating efficiency of magnetoferritin and potential future applications for tumor magnetic hyperthermia treatment and heat-triggered drug release.
Keywordmagnetic nanoparticles magnetic hyperthermia magentoferritin Neel relaxation specific loss power intrinsic loss power
DOI10.3390/nano9101457
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences
WOS KeywordCANCER-TREATMENT ; LOSS POWER ; HYPERTHERMIA ; FERRITIN ; OXIDE ; CELLS ; FLUID ; SIZE
Language英语
Funding ProjectNational Natural Science Foundation of China[41621004] ; Key Program of Chinese Academy of Sciences[QYZDJ-SSW-DQC024]
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences ; Key Program of Chinese Academy of Sciences
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS IDWOS:000495666800112
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iggcas.ac.cn/handle/132A11/95696
Collection地球与行星物理院重点实验室
Corresponding AuthorPan, Yongxin
Affiliation1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp,Paleomagnetism & Geochronol L, Beijing 100029, Peoples R China
2.Chinese Acad Sci, Inst Earth Sci, Beijing 100029, Peoples R China
3.Univ Chinese Acad Sci, Coll Earth & Planetary Sci, Beijing 100049, Peoples R China
First Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Xu, Huangtao,Pan, Yongxin. Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field[J]. NANOMATERIALS,2019,9(10):14.
APA Xu, Huangtao,&Pan, Yongxin.(2019).Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field.NANOMATERIALS,9(10),14.
MLA Xu, Huangtao,et al."Experimental Evaluation on the Heating Efficiency of Magnetoferritin Nanoparticles in an Alternating Magnetic Field".NANOMATERIALS 9.10(2019):14.
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