IGGCAS OpenIR  > 地球与行星物理院重点实验室
Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo
Cai, Yao1,2; Deng, Tian2,3; Pan, Yongxin1; Zink, Jeffrey, I2,3
2020-08-09
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Pages13
AbstractMesoporous silica nanoparticles (MSNs) functionalized with redox-sensitive or pH-sensitive nanovalves for doxorubicin delivery and release by using recombinant human H chain ferritin (HFn) as a cap have been designed and fabricated. In both cases, transmission electron microscope observatory, dynamic light scattering change, Fourier transform infrared spectra examination, thermogravimetric analysis show that HFn can be chemically bonded to MSNs while retaining its ability to target transferrin receptor 1 (TfR1). Cargo loading and release studies demonstrate that HFn is an efficient capping agent, blocking the pores of MSN preventing cargo molecules from diffusing out, and is responsive to redox stimuli or pH changes. More importantly, HFn can not only cap the MSNs, but also enables targeted cargo delivery to malignant cells by binding to the TfR1 that has been overexpressed in various tumors, which can be reflected by the cell viability and fluorescence microscope analysis results comparing with cyclodextrin as the capping agent and TfR1 blocking assay. The in vivo study reveals the excellent efficacy of doxorubicin loaded and HFn capped MSNs on suppression of tumor growth. The new developed drug delivery system features mutually benefit and mutually support, providing strategy for achieving specific-site therapeutics delivery systems.
Keyworddrug delivery ferritin mesoporous silica nanoparticle targeting
DOI10.1002/adfm.202002043
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund
WOS KeywordDELIVERY SYSTEM ; H-FERRITIN ; THERAPY ; NANOCAGES ; PLATFORM ; MOXIFLOXACIN ; GATEKEEPERS ; APOFERRITIN ; NANOVALVES ; EFFICACY
Language英语
Funding ProjectNational Natural Science Foundation of China[41621004] ; National Natural Science Foundation of China[41704072] ; China Postdoctoral Science Foundation[2017M610979] ; Zink Student Research Support Fund
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; China Postdoctoral Science Foundation ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund ; Zink Student Research Support Fund
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000557410100001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iggcas.ac.cn/handle/132A11/97607
Collection地球与行星物理院重点实验室
Corresponding AuthorCai, Yao; Zink, Jeffrey, I
Affiliation1.Chinese Acad Sci, Inst Geol & Geophys, Key Lab Earth & Planetary Phys, Biogeomagnetism Grp, Beijing 100029, Peoples R China
2.Univ Calif Los Angeles, Dept Chem & Biochem, Los Angeles, CA 90095 USA
3.Univ Calif Los Angeles, Calif Nano Syst Inst, Los Angeles, CA 90095 USA
First Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Corresponding Author AffilicationInstitute of Geology and Geophysics, Chinese Academy of Sciences
Recommended Citation
GB/T 7714
Cai, Yao,Deng, Tian,Pan, Yongxin,et al. Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo[J]. ADVANCED FUNCTIONAL MATERIALS,2020:13.
APA Cai, Yao,Deng, Tian,Pan, Yongxin,&Zink, Jeffrey, I.(2020).Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo.ADVANCED FUNCTIONAL MATERIALS,13.
MLA Cai, Yao,et al."Use of Ferritin Capped Mesoporous Silica Nanoparticles for Redox and pH Triggered Drug Release In Vitro and In Vivo".ADVANCED FUNCTIONAL MATERIALS (2020):13.
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